Ototoxicity of aminoglycosides correlated with their action on monomolecular films of polyphosphoinositides
نویسندگان
چکیده
منابع مشابه
Ototoxicity of aminoglycosides correlated with their action on monomolecular films of polyphosphoinositides.
The ototoxicities of eight aminoglycoside antibiotics and fragments were measured quantitatively by cochlear perfusion in the guinea pig. Perilymphatic spaces were perfused for 1 hr with ‘artificial perilymph’ containing 10 mM drug, during which time continuous measurements of cochlear microphonic potentials were made. Kanamycin B and neomycin I3 caused the most rapid decline of cochlear microp...
متن کاملInteractions of neomycin with monomolecular films of polyphosphoinositides and other lipids.
The interactions of calcium and the aminoglycosidic antibiotic, neomycin, with various lipids were investigated in monomolecular films. Lipids were spread over a subphase of 0.05 M N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid, pH 7.0, and NaCl to give an ionic strength of 0.2. Measurements of surface pressure (pi) were taken with a Wilhelmy balance. In the absence of Ca2+, 1 muM--1 mM ne...
متن کاملarchitecture and engineering of nanoscale sculptured thin films and determination of their properties
چکیده ندارد.
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 1980
ISSN: 0006-2952
DOI: 10.1016/0006-2952(80)90382-2